Update on estimation of mutation rates using data from fluctuation experiments.

نویسنده

  • Qi Zheng
چکیده

This note discusses a minor mathematical error and a problematic mathematical assumption in Luria and Delbrück's (1943) classic article on fluctuation analysis. In addition to suggesting remedial measures, the note provides information on the latest development of techniques for estimating mutation rates using data from fluctuation experiments.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bayesian procedures for the estimation of mutation rates from fluctuation experiments.

Bayesian procedures are developed for estimating mutation rates from fluctuation experiments. Three Bayesian point estimators are compared with four traditional ones using the results of 10,000 simulated experiments. The Bayesian estimators were found to be at least as efficient as the best of the previously known estimators. The best Bayesian estimator is one that uses (1/m2) as the prior prob...

متن کامل

Estimation of LOS Rates for Target Tracking Problems using EKF and UKF Algorithms- a Comparative Study

One of the most important problem in target tracking is Line Of Sight (LOS) rate estimation for using from PN (proportional navigation) guidance law. This paper deals on estimation of position and LOS rates of target with respect to the pursuer from available noisy RF seeker and tracker measurements. Due to many important for exact estimation on tracking problems must target position and Line O...

متن کامل

Unbiased Estimation of Mutation Rates under Fluctuating Final Counts

Estimation methods for mutation rates (or probabilities) in Luria-Delbrück fluctuation analysis usually assume that the final number of cells remains constant from one culture to another. We show that this leads to systematically underestimate the mutation rate. Two levels of information on final numbers are considered: either the coefficient of variation has been independently estimated, or th...

متن کامل

Assessing the Exchange Rate Fluctuation on Tehrans Stock Market Price: A GARCH Application

This paper empirically investigates the exchange rate effects of Iranian Rial against Dollar (Rial vs.US) on stock prices in Iran. The sample period for the study has been taken from March 20, 2004 to March 20, 2010 using daily nominal exchange rate of Rial /us and daily closing values of Tehran Stock Exchange. Generalized Autoregressive Conditional Heteroskedasticity (GARCH) model has been use...

متن کامل

Large Scale Experiments Data Analysis for Estimation of Hydrodynamic Force Coefficients

This paper describes the various frequency domain methods which may be used to analyze experiments data on the force experienced by a circular cylinder in wave and current to estimate drag and inertia coefficients for use in Morison’s equation. An additional approach, system identification techniques (SIT) is also introduced. A set of data obtained from experiments on heavily roughened circular...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Genetics

دوره 171 2  شماره 

صفحات  -

تاریخ انتشار 2005